Temperature experiments on nerve and muscle membranes of frogs
Identifieur interne : 001591 ( Main/Exploration ); précédent : 001590; suivant : 001592Temperature experiments on nerve and muscle membranes of frogs
Auteurs : Wolfgang Schwarz [États-Unis, Allemagne]Source :
- Pflügers Archiv [ 0031-6768 ] ; 1979-10-01.
English descriptors
- Teeft :
- Absolute rate theory, Activation energy, Activation enthalpies, Activation enthalpy, Anaesthetic, Anaesthetic benzocaine, Arrhenius, Arrhenius plot, Arrhenius plots, Benzocaine, Cell membranes, Channel gating, Channel protein, Conductance, Critical value, Depolarizing, Depolarizing pulse, Different temperatures, Divalent cations, Drug molecules, Enthalpy, Excitable membranes, External potassium, External solution, Fibre, Frankenhaeuser, Frog, Frog nerve, Gating, Higher temperatures, Hille, Hysteresis, Hysteresis width, Inactivation, Integral proteins, Internal solution, Kinetics, Lipid, Lipid phase, Lipid phase transition, Local anaesthetics, Locust muscle, Lond, Lower temperatures, Membrane, Membrane lipids, Muscle fiber, Muscle fibers, Muscle membranes, Muscle preparations, Myelinated, Myelinated nerve, Myelinated nerve fibers, Myelinated nerve fibres, Node, Other hand, Peak currents, Pflfigers arch, Pfliigers arch, Pfltigers arch, Phase change, Phase transition, Phase transitions, Physiol, Quantitative description, Ranvier, Ranvier nodes, Rate constants, Receptor, Same computer, Same temperature, Schwarz, Slow changes, Slow inactivation, Slow sodium inactivation, Sodium channels, Sodium currents, Solid lines, Standardized pulses, Straight lines, Subsequent heating, Temperature change, Temperature changes, Temperature dependence, Temperature experiments, Temperature jump experiments, Temperature range, Time constants, Time course, Transition temperature, Transition temperatures, Voltage dependence, Xenopus laevis.
Abstract
Abstract: The influence of temperature changes in the range of 25°C to −6°C on the time constants of Na activation (τm) and inactivation (τh) was studied in twitch muscle fibers and the node of Ranvier under voltage-clamp conditions. Arrhenius plots of τm and τh exhibit a change in activation enthalpy at temperatures below 10°C. Cooling and subsequent heating induce a hystersis in the temperature dependence of τm and τh Ni2+ and UO 2 2+ increase the hysteresis width. With fast temperature changes the gating kinetics relax to their new values more slowly than the temperature change. Hence, temperature must be changed more slowly than 5°C/min if an additional apparent hysteresis due simply to this relaxation is to be avoided. The data are explained by the hypothesis of a phase transition in the membrane lipids. This conception is favoured over a temperature-induced change in protein conformation, since the neutral local anaesthetic benzocaine shows use-dependent block as if low temperature restricted the access of the drug through the lipid phase to its receptor.
Url:
DOI: 10.1007/BF00585900
Affiliations:
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Physiologisches Institut, Universität des Saarlandes, D-6650, Homburg (Saar)</wicri:regionArea><wicri:noRegion>Homburg (Saar)</wicri:noRegion><wicri:noRegion>Homburg (Saar)</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Pflügers Archiv</title><title level="j" type="sub">European Journal of Physiology</title><title level="j" type="abbrev">Pflugers Arch.</title><idno type="ISSN">0031-6768</idno><idno type="eISSN">1432-2013</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1979-10-01">1979-10-01</date><biblScope unit="volume">382</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="27">27</biblScope><biblScope unit="page" to="34">34</biblScope></imprint><idno type="ISSN">0031-6768</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0031-6768</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Absolute rate theory</term><term>Activation energy</term><term>Activation enthalpies</term><term>Activation enthalpy</term><term>Anaesthetic</term><term>Anaesthetic benzocaine</term><term>Arrhenius</term><term>Arrhenius plot</term><term>Arrhenius plots</term><term>Benzocaine</term><term>Cell membranes</term><term>Channel gating</term><term>Channel protein</term><term>Conductance</term><term>Critical value</term><term>Depolarizing</term><term>Depolarizing pulse</term><term>Different temperatures</term><term>Divalent cations</term><term>Drug molecules</term><term>Enthalpy</term><term>Excitable membranes</term><term>External potassium</term><term>External solution</term><term>Fibre</term><term>Frankenhaeuser</term><term>Frog</term><term>Frog nerve</term><term>Gating</term><term>Higher temperatures</term><term>Hille</term><term>Hysteresis</term><term>Hysteresis width</term><term>Inactivation</term><term>Integral proteins</term><term>Internal solution</term><term>Kinetics</term><term>Lipid</term><term>Lipid phase</term><term>Lipid phase transition</term><term>Local anaesthetics</term><term>Locust muscle</term><term>Lond</term><term>Lower temperatures</term><term>Membrane</term><term>Membrane lipids</term><term>Muscle fiber</term><term>Muscle fibers</term><term>Muscle membranes</term><term>Muscle preparations</term><term>Myelinated</term><term>Myelinated nerve</term><term>Myelinated nerve fibers</term><term>Myelinated nerve fibres</term><term>Node</term><term>Other hand</term><term>Peak currents</term><term>Pflfigers arch</term><term>Pfliigers arch</term><term>Pfltigers arch</term><term>Phase change</term><term>Phase transition</term><term>Phase transitions</term><term>Physiol</term><term>Quantitative description</term><term>Ranvier</term><term>Ranvier nodes</term><term>Rate constants</term><term>Receptor</term><term>Same computer</term><term>Same temperature</term><term>Schwarz</term><term>Slow changes</term><term>Slow inactivation</term><term>Slow sodium inactivation</term><term>Sodium channels</term><term>Sodium currents</term><term>Solid lines</term><term>Standardized pulses</term><term>Straight lines</term><term>Subsequent heating</term><term>Temperature change</term><term>Temperature changes</term><term>Temperature dependence</term><term>Temperature experiments</term><term>Temperature jump experiments</term><term>Temperature range</term><term>Time constants</term><term>Time course</term><term>Transition temperature</term><term>Transition temperatures</term><term>Voltage dependence</term><term>Xenopus laevis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The influence of temperature changes in the range of 25°C to −6°C on the time constants of Na activation (τm) and inactivation (τh) was studied in twitch muscle fibers and the node of Ranvier under voltage-clamp conditions. Arrhenius plots of τm and τh exhibit a change in activation enthalpy at temperatures below 10°C. Cooling and subsequent heating induce a hystersis in the temperature dependence of τm and τh Ni2+ and UO 2 2+ increase the hysteresis width. With fast temperature changes the gating kinetics relax to their new values more slowly than the temperature change. Hence, temperature must be changed more slowly than 5°C/min if an additional apparent hysteresis due simply to this relaxation is to be avoided. The data are explained by the hypothesis of a phase transition in the membrane lipids. This conception is favoured over a temperature-induced change in protein conformation, since the neutral local anaesthetic benzocaine shows use-dependent block as if low temperature restricted the access of the drug through the lipid phase to its receptor.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Washington (État)</li></region><settlement><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Schwarz, Wolfgang" sort="Schwarz, Wolfgang" uniqKey="Schwarz W" first="Wolfgang" last="Schwarz">Wolfgang Schwarz</name></region></country><country name="Allemagne"><noRegion><name sortKey="Schwarz, Wolfgang" sort="Schwarz, Wolfgang" uniqKey="Schwarz W" first="Wolfgang" last="Schwarz">Wolfgang Schwarz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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